What combination of enzymes is commonly elevated in cases of acute pancreatitis?

• A. Myoglobin and LD
• B. Amylase and lipase
• C. CK and AST
• D. Troponin and CK-MB

Answer: (B)

In cases of acute pancreatitis, the combination of amylase and lipase is commonly elevated. Amylase is an enzyme that helps in the digestion of carbohydrates, and lipase is crucial for fat digestion. When the pancreas becomes inflamed, as seen in acute pancreatitis, it releases an excess of these enzymes into the bloodstream.

Both amylase and lipase levels can rise significantly, often with lipase being more specific and sensitive to pancreatic injury than amylase. The increase in these enzymes is due to the damage to pancreatic cells and duct obstruction that allows these enzymes to leak into the circulation. While elevated levels of amylase can occur in conditions apart from pancreatic diseases, such as salivary gland inflammation or intestinal obstruction, the concurrent elevation of lipase strongly indicates acute pancreatitis.

This diagnostic pattern of elevated amylase and lipase is useful not only for confirming a diagnosis of acute pancreatitis but also for monitoring the severity and course of the disease. The other answer choices represent enzymes linked to different conditions or organ systems, making them less relevant in the context of acute pancreatitis.